Internal Medicine

26 March 2025 12:49

💢 Diagnosis and management of chronic
rhinosinusitis


🆔 @internalmed
.

Internal Medicine

25 March 2025 17:02

💢 SGLT‑2 inhibitors and diabetic ketoacidosis


🆔 @internalmed
.

Internal Medicine

23 March 2025 17:41

💢 Five things to know about Vitiligo


🆔 @internalmed
.

Internal Medicine

23 March 2025 00:46

فانا: نسل جدید داروهای کاهش وزن در راهند

🔹داروی Orforglipron، ایلای لیلی، ۲۰۲۶
🔹داروی CagriSema، نوو نوردیسک، ۲۰۲۶
🔹داروی Survodutide، بوهرینگر اینگلهایم، ۲۰۲۷
🔹داروی Retatrutide، ایلای لیلی، ۲۰۲۷
🔹داروی MariTide، امژن، ۲۰۲۸ و بعد از آن
🔹داروی Bimagrumab، ایلای لیلی، ۲۰۲۸ و بعد از آن
🔹داروی Monlunabant، نوو نوردیسک، ۲۰۲۸ و بعد از آن/نیچر

www.daroovasalamat.ir/news/58104
@phanair

Internal Medicine

20 March 2025 10:54

نوروز زیبا مبارک 🎉
امید که سال جدید سال شادمانی
و خبرهای خوش باشد. ✨💐
امیرعلی سهراب‌پور

Internal Medicine

15 March 2025 21:42

🔥

💢 Alcohol and Blood Pressure Fact Sheet

➖ High quality clinical and experimental studies show that alcohol intake increases blood pressure, especially in the hours and days after consumption and for higher levels of alcohol use.

➖High quality studies with randomization find no evidence that low level alcohol use has beneficial effects on blood pressure or hypertension


👇
https://alcoholandsociety.report/


🆔 @internalmed
.

Internal Medicine

13 March 2025 19:14

💢 Does Continuing Metformin in Hospitalized Patients with Type 2 Diabetes Affect Posthospitalization Outcomes?


An observational study suggests inpatient continuation is associated with lower risk for hypoglycemia and death after discharge.

Current guidelines recommend holding metformin in hospitalized patients, given hospitalized patients' potential excess risk for lactic acidosis due to hemodynamic instability, hypoxia, congestive heart failure (CHF), or acute kidney injury.

However, critics contend that many patients without contraindications should continue to receive metformin in the hospital since no evidence shows that it is harmful, and it might have benefits such as avoiding hypoglycemia, which is more common with insulin.

Researchers conducted a propensity-matched observational study in 67,000 adult patients (97% men) with type 2 diabetes who were admitted to Veterans Health Affairs (VHA) hospitals. Half of patients continued and half discontinued metformin during hospitalization.

Patients with glomerular filtration rate (GFR) ≤30 mL/minute/1.73 m2 and those who died during the index hospitalization were excluded.

Importantly, patients with sepsis, CHF, gastrointestinal bleeding, pancreatitis, and other comorbidities were included.

Within 90 days of discharge, those who received metformin were significantly less likely to develop hypoglycemia (the primary outcome; 1.5% vs. 1.8%), perhaps because recipients of metformin during hospitalization were less likely to be discharged on insulin.

The metformin group also had significantly lower 90-day mortality and lower readmission rates (absolute difference, ≈1% lower for each outcome).

COMMENT
This study is notable because of the researchers' inclusion of patients with comorbidities that are associated with risk for lactic acidosis and (presumably) worse outcomes.

Backed by these findings, clinicians can reasonably assume that continuing metformin in hemodynamically stable hospitalized patients with GFR >30 mL/minute/1.73 m2 is safe and might improve outcomes after hospital discharge. Although most patients in this study were men, there is no obvious reason that the findings wouldn't apply to women.


🆔 @internalmed
.

Internal Medicine

06 March 2025 20:15

💢 Does vitamin D supplementation reduce the risk of severe asthma exacerbations or improve asthma symptoms?


🆔 @Internalmed
.

Internal Medicine

28 February 2025 14:57

💢 Many Young Females Experience Perimenopausal Symptoms


A recent study published in npj Women's Health found that many women aged 30-35 may be experiencing untreated perimenopausal symptoms.

The study analyzed self-reported data from over 4,400 women and found that 55.4% of women in this age group reported moderate to severe perimenopausal symptoms. However, most women did not seek treatment for their symptoms until they were 56 or older.

The study also found that women in this age group were more likely to experience psychological symptoms such as depression, irritability, and anxiety, which tended to occur before physical symptoms.

Many women assume that menopause is a 50s problem, and therefore, dismiss their symptoms as stress, aging, or lifestyle factors. However, perimenopause can start as early as the early to mid-30s, and ignoring symptoms can lead to unnecessary suffering.

The study's authors suggest that hormone replacement therapy (HRT) can be a helpful resource for some women, but it is essential to see a practitioner who understands the intricacies of hormone therapy.

Lifestyle changes, such as getting adequate sleep, staying hydrated, eating healthy foods, and engaging in gentle exercise and stress-reducing activities, can also help alleviate symptoms.

Additionally, evaluating and treating the gut microbiome, as well as using lubricants, moisturizers, and pelvic floor exercises, may provide relief for some women.

Overall, the study's findings emphasize the importance of recognizing and addressing perimenopausal symptoms, regardless of age. By seeking help and making lifestyle changes, women can find relief and improve their overall quality of life.


🆔 @Internalmed
.

Internal Medicine

28 February 2025 11:23

💢 Medical Mystery Solved — A Swell Diagnosis | NEJM

https://youtu.be/8Ds16fscqKQ?si=ySip3bpdOUX4kg92


🆔 @Internalmed
.

Internal Medicine

23 February 2025 19:45

💢 Weight Loss Drugs Removed from FDA Shortage List

https://www.inc.com/reuters/novos-weight-loss-drugs-removed-from-fda-shortage-list/91151263


🆔 @Internalmed
.

Internal Medicine

23 February 2024 12:36

💢 Chylothorax


🆔 @Internalmed
.

Internal Medicine

20 February 2024 18:23

💢 Statins may lower risk for any dementia among adults with heart failure


https://www.healio.com/news/cardiology/20240220/statins-may-lower-risk-for-any-dementia-among-adults-with-heart-failure


🆔 @Internalmed
.

Internal Medicine

19 February 2024 09:33

💢 Behçet’s Syndrome


🆔 @Internalmed
.

Internal Medicine

18 February 2024 16:39

https://podcasts.apple.com/us/podcast/harrisons-podclass-internal-medicine-cases-and-board-prep/id1453765092?i=1000641230921


🆔 @Internalmed
.

Internal Medicine

26 March 2025 10:29

💢 🎧 Diagnosis, Treatment, and Prognosis of ADPKD

https://podcasts.apple.com/us/podcast/jama-clinical-reviews/id1027430378?i=1000700613183


🆔 @internalmed
.

Internal Medicine

24 March 2025 17:43

💢 Falls in older adults


🆔 @internalmed
.

Internal Medicine

23 March 2025 01:29

💢 Lupus vulgaris (skin TB) in a 58-year-old man


🆔 @internalmed
.

Internal Medicine

22 March 2025 22:32

💢 Sarcoidosis with diffuse purplish erythematous plaques on the hands

https://www.ccjm.org/content/ccjom/92/3/145.full.pdf


🆔 @internalmed
.

Internal Medicine

17 March 2025 21:46

💢 🎧 Chronic Myeloid Leukemia: A Review

https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2025.2283


🆔 @internalmed
.

Internal Medicine

14 March 2025 17:33

💢 HPV vaccination: How the world can eliminate cervical cancer


👇
https://ourworldindata.org/hpv-vaccination-world-can-eliminate-cervical-cancer


🆔 @internalmed
.

Internal Medicine

11 March 2025 16:11

💢 Recent advances in the management of knee osteoarthritis: a narrative review


🆔 @Internalmed
.

Internal Medicine

01 March 2025 13:29

💢 Diagnostic Approach to Abnormal Alkaline Phosphatase Value

https://www.mayoclinicproceedings.org/article/S0025-6196(24)00611-6/fulltext?rss=yes


🆔 @Internalmed
.

Internal Medicine

28 February 2025 14:29

💢 Is Semaglutide Use Associated with Nonarteritic Anterior Ischemic Optic Neuropathy?

Nonarteritic anterior ischemic optic neuropathy (NAION) is a rare cause of optic neuropathy that can result in blindness. A recent study suggested an association between NAION and glucagon-like peptide-1 (GLP-1)–receptor agonist semaglutide in an ophthalmology referral population.

To examine a potential association in the general population, researchers evaluated 14 U.S. databases with information on 37 million patients with type 2 diabetes who used semaglutide or other common diabetes medications. Two study designs were used to help limit confounding: A new-user cohort (800,000 patients) with propensity-score matching and a self-controlled case series (40,000 patients).

In the propensity-score analysis, semaglutide was associated with significant excess risk for NAION compared with empagliflozin (hazard ratio, 2.3). In the self-controlled case analysis, semaglutide and exenatide exposures were associated with a significantly higher incidence of NAION (HRs, 1.5 and 1.6, respectively). The NAION incidence rate among new semaglutide users ranged from 9 to 15 per 100,000 person-years, depending on the definition used to identify NAION.

This study adds to the growing evidence of an association between semaglutide and NAION; similar findings were reported in a recent population-based Danish study. Although this body of observational research doesn't prove causality, informing patients about this rare potential complication when initiating semaglutide seems prudent. The mechanism remains unclear, but editorialists note the presence of GLP-1 receptors in retinal ganglion cells, which form the optic nerve.


🆔 @Internalmed
.

Internal Medicine

25 February 2025 20:37

💢 Conversion between steroid


🆔 @Internalmed
.

Internal Medicine

23 February 2024 14:05

💢 Rusfertide for Control of Erythrocytosis in Polycythemia Vera


🆔 @Internalmed
.

Internal Medicine

22 February 2024 14:45

/channel/+jb8aGHkDgq80MDMy

Internal Medicine

20 February 2024 08:58

💢 GLP-1s associated with reduced risk for depression, anxiety in patients with diabetes

👇
https://www.healio.com/news/primary-care/20240219/glp1s-associated-with-reduced-risk-for-depression-anxiety-in-patients-with-diabetes


🆔 @Internalmed
.

Internal Medicine

19 February 2024 05:32

💢 Clinical Manifestations of Behçet’s Syndrome.

Shown are the typical features of Behçet’s syndrome, including an oral ulcer (Panel A); a papulopustular lesion (Panel B); erythema nodosum (Panel C); capillary impairment and vascular leakage on retinal fluorescein angiography (Panel D); a brain-stem inflammatory lesion on a T2-weighted axial magnetic resonance imaging sequence, with an edematous, protuberant FLAIR (fluid attenuated inversion recovery) hypersignal extending to the middle cerebellar peduncles and discrete hypertrophy (Panel E); and aneurysmal dilatation of a pulmonary-artery branch (Panel F, arrowhead).


🆔 @Internalmed
.

Internal Medicine

16 February 2024 17:26

💢 Postinfectious cough in adults


🆔 @Internalmed
.