Telegram-канал medicals_2017 - Clinical Medicine: Adults only

Clinical Medicine

08 Apr 2025 23:44

👨🏻‍⚕ : what is your name ?
💊 : my name is ceftriaxone
👨🏻‍⚕: what is your work ?
💊 : Antibiotics
👨🏻‍⚕: Tell me about yourself
💊 : I am from third Generation cephalosporin
👨🏻‍⚕ : what is your mechanism of action ?
Ceftriaxone 💊 : I'm Bacteriocidal activity results from inhibiting cell-wall synthesis , broad-spectrum against gram-negative ; has lower efficacy against gram-positive organisms
👨🏻‍⚕ : Are there's any oral compound of You ?
Ceftriaxone 💊 : No , I am only in the form of injectable solution or powder use for IV / IM
👨🏻‍⚕ : what about metabolism of you ?
Ceftriaxone 💊 : metabolized in liver
👨🏻‍⚕ What about your elimination ?
Ceftriaxone 💊 : Urine " 33% - 67% unchanged "
👨🏻‍⚕ : nurse want to ask you How ceftriaxone 💊 administration ?
Ceftriaxone 💊 : this is very important point ,
🔻You must to do Test for allergy before administration very very important heart
I am incompatible with with LR ...
👨🏻‍⚕ : so I understand some patient have hypersensitivity reaction to you and maybe fetal , also you are incompatible with LR ,
But I have Questione also there's NEWS that say Calcium is Your Enemy ?
Ceftriaxone 💊 : when I meet calcium or any calcium containing fluids , we form parecipate which maybe fetal especially in neonates
👨🏻‍⚕: what is the contraindication of you ?
Ceftriaxone 💊 : do not use me in hyperbilirubinemic neonates
Don't use me with intravenous calcium-containing .
Take care drug interactions
Intravenous administration of ceftriaxone solutions containing lidocaine
Don't use ceftriaxone in neonate
👨🏻‍⚕ What is Warning ⚠️ or percution of your uses ?
Ceftriaxone 💊 :
🔻 Elevated INR
🔻 Superinfection especially in prolonged use
🔻 Renal/hepatic impairment (concurrent): Use with caution in patients with concurrent hepatic dysfunction (impaired biliary
excretion) and severe kidney disease .
🔻 Abnormal gallbladder sonograms reported, possibly the result of ceftriaxone-calcium precipitates; discontinue if signs or symptoms of gallbladder disease occur
👨🏻‍⚕ : what is your category in pregnancy ?
Ceftriaxone💊 : pregnancy category B
👨🏻‍⚕ : what about your distribution ?
Ceftriaxone 💊 : Distributed throughout body, including gallbladder, lungs, bone, bile, and CSF (higher concentrations achieved when meninges are inflamed); crosses placenta; enters amniotic fluid and breast milk
👨🏻‍⚕ : what is your Drug Interactions ?
Ceftriaxone 💊 : it's list need tim
👨🏻‍⚕ : What is your advers effect " significant "?
Ceftriaxone 💊 : 👉Ceftriaxone-calcium precipitation
👉 Hemolytic anemia
👉 Hypersensitivity reactions (immediate and delayed)
👉 Kernicterus
👨🏻‍⚕ What is other adverse effect ?
Ceftriaxone 💊 :
>10%:
Dermatologic: Skin tightness (IM; local)
1% to 10%:

Dermatologic: Skin rash (2%)

Gastrointestinal: Diarrhea (3%)

Hematologic & oncologic: 🔻🔻Eosinophilia (6%), leukopenia (2%), thrombocytosis (5%)

🔻Hepatic: Increased serum alanine aminotransferase (3%), increased serum aspartate aminotransferase (3%)

🔻Local: Pain at injection site (≤1%), tenderness at injection site (≤1%)

Renal: Increased blood urea nitrogen (1%)

👨🏻‍⚕ : this first part of the meeting 🤝 with Mr Ceftriaxone
👨🏻‍⚕ : we will compelet Tomorrow our meeting with thank you for you
Ceftriaxone 💊 : welcome 🤗 to you and to every members in this beautiful channel , don't forget to React

#meeting_drug
#first_drug
#part1
@pharmacology2017