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Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) @rezaei_nima
GDF-15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme
New Paper by USERN Interest Group
🌀Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis.
🌀Growth differentiation factor 15 (GDF‐15) belongs to transforming growth factor‐β superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis.
🌀GDF‐15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage.
Source: https://doi.org/10.1002/jcp.30289
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International Childhood Cancer Day 2021
👶🏻👶🏾👧🏻👧🏾
🔹Better survival is achievable #throughourhands.
🔹Support via sending virtual handprint.
🔹More information: https://iccd.care/
🧒🏻🧒🏾👦🏻👦🏾
@niima_usern
❄️Winter Research Week❄️
🏆 with special support from Springer publisher.
🔹 Kindly thanks for your interest, due to limited capacity, following workshops in the "Winter Research Week" have only few seats available!
Please notice that you should register and finalize your registration, before remaining seats are sold out.
⭕️ Scientific Writing by Prof. Nima Rezaei
Virtual: sold out❌
In-person: 1 seat
⭕️ Journal Selection and Paper Submission by Prof. Nima Rezaei
Virtual: sold out❌
In-person: 3 seats
⭕️ Statistics by Dr. Amene Saghazadeh
Virtual: 7 seats
In-person: 4 seats
⭕️ Systematic Review by Dr. Amene Saghazadeh
Virtual: sold out❌
In-person: 7 seats
⭕️ Meta-Analysis by Dr. Amene Saghazadeh
Virtual: sold out❌
In-person: 6 seats
⭕️ Publishing Books with International Publishers by Prof. Nima Rezaei
Virtual: sold out❌
In-person: 4 seats
🔻 Registration and more information.
📧researchweek.usern@gmail.com
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@niima_usern
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Application of Platelet Rich Fibrin in Tissue Engineering: Focus on Bone Regeneration
New Paper by USERN Interest Group
🌀Bone tissue engineering (BTE) is a strategy for reconstructing bone lesions, which is rapidly developing in response to higher demands for bone repairing.
🌀The most important reason for using platelet-rich formulations in bone regeneration is based on releasing growth factors from alpha granules in platelets, which can induce osteogenesis.
🌀The presence of fibrin nano-fiber structures as a constituent can provide a good substrate for cell attachments.
🌀This study attempts to review the history, structure, and biology of platelet-rich fibrin (PRF) as well as in vitro, pre-clinical, and clinical studies on the use of PRF for bone regeneration.
Source: https://doi.org/10.1080/09537104.2020.1869710
🔴Join the winter workshops: Registration
🌐 https://usern.tums.ac.ir/Group/Info/NIIMA
✉️ niima.usern@gmail.com
@niima_usern
❄️Winter Research Week❄️
🏆 with special support from Springer publisher.
🔹 Kindly thanks for your interest, due to limited capacity, following workshops in the "Winter Research Week" have only few seats available!
Please notice that you should register and finalize your registration, before remaining seats are sold out.
⭕️ Scientific Writing by Prof. Nima Rezaei
Virtual: 2 seats
In-person: 8 seats
⭕️ Journal Selection and Paper Submission by Prof. Nima Rezaei
Virtual: 13 seats
In-person: 10 seats
⭕️ Statistics by Dr. Amene Saghazadeh
Virtual: 22 seats
In-person: 10 seats
⭕️ Systematic Review by Dr. Amene Saghazadeh
Virtual: 11 seats
In-person: 13 seats
⭕️ Meta-Analysis by Dr. Amene Saghazadeh
Virtual: 18 seats
In-person: 13 seats
⭕️ Publishing Books with International Publishers by Prof. Nima Rezaei
Virtual: 11 seats
In-person: 12 seats
🔻 Registration and more information.
📧researchweek.usern@gmail.com
@usern_net
@niima_usern
@srmeg_usern
@nini_usern
@cip_usern
❄️USERN proudly presents:
Scientific Writing Workshop
🔹Instructor: Prof. Nima Rezaei
🔹Special supporter: Springer publisher
🏆Springer's award to the best participant of this workshop:
"English for Writing Research Papers" book
🔹February 27th, 2021 (15:00 to 19:00)
🔻Limited seats.
🔻For registration and more information click/tap here.
📧researchweek.usern@gmail.com
@usern_net
@niima_usern
@srmeg_usern
@nini_usern
@cip_usern
Investigating the possible association between NLRP3 gene polymorphisms and myasthenia gravis
New Paper by USERN Interest Group
🌀In this case‐control study, we investigated the association between NLRP3 single‐nucleotide polymorphisms (SNPs) rs10754558, rs3806265, rs4612666, and rs35829419 and myasthenia gravis (MG).
🌀A total of 93 blood samples from eligible Iranian patients with MG and 56 samples from healthy controls were obtained. The NLRP3 rs3806265 “C” allele was significantly more frequent in MG patients (P<0.001; OR=2.33, 95% CI: 1.4‐4.0) than controls. The "CC" genotype of this SNP was found in 18.27% of patients, but none of the controls (P<0.001). The distribution of other SNPs was similar between the groups.
Source: https://doi.org/10.1002/mus.27193
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COVID-19 in patients with cancer: Risks and precautions
New Paper on COVID-19 by USERN Interest Group
🌀It has been reported that those who suffer from cancer (especially lung cancer and hematological malignancies) are at higher risk of serious complications and death from COVID-19.
🌀Some cancer treatments such as CAR T cell therapy can produce a cytokine storm, which is also a hallmark of severe COVID-19. Therefore, patients receiving CAR T cells are at higher risk if they become infected with COVID-19, and could be treated with anti-cytokine approaches.
Source: https://doi.org/10.1016/j.ajem.2021.01.067
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Every Week, One UQR
✔️This week’s theme:
“Mum, why are you so kind?”
💢Press the link to read it:
https://bit.ly/2MDvTAP
#UQR
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Publishing Books with International Publishers
Instructor: Prof. Nima Rezaei
Editor-in-Chief of Book Series Published by Springer and Elsevier.
This workshop is Supported by Springer.
🗓 March 4th
🕰 15:00 to 19:00
🌀For registration and more information, please click/tap here.
❌Registration deadline: February 19th
📧researchweek.usern@gmail.com
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@nini_usern
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World Cancer Day, Feb 4th
#IAmAndIWill
🔶Published Books with NIIMA Affiliation Related to Cancer:
🔸Cancer Immunotherapy for Organ-Specific Tumors, Springer, 2015
https://www.springer.com/gp/book/9783662513842
🔸Cancer Immunology: A Translational medicine Context (2nd edition), Springer, 2020
https://www.springer.com/gp/book/9783030308445
@niima_usern
Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients
New Paper on COVID-19 by USERN Interest Group
🌀Because the development of effective vaccines or novel drugs could take several months (if not years), repurposing existing drugs is considered a more efficient strategy that could save lives now.
🌀We found that statin use appeared to be associated with a lower risk of morbidity [HR = 0.85, 95% CI = (0.02, 3.93), P = 0.762] and lower risk of death [(HR = 0.76; 95% CI = (0.16, 3.72), P = 0.735)]; however, these associations did not reach statistical significance.
🌀Although we could not demonstrate a significant association between statin use and a reduction in mortality in patients with COVID19, we do feel that our results are promising and of clinical relevance.
Source: https://doi.org/10.1186/s41231-021-00082-5
🔴Join our winter workshops: Registration
🌐 https://usern.tums.ac.ir/Group/Info/NIIMA
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@niima_usern
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🎨7th International Festival of Paintings for Pediatric Patients
🗓November 2021
https://usern.tums.ac.ir/SiteContent/Show/heart
❌Deadline for submission of artworks: June 9th, 2021
📧High resolution scan copy of paintings should be sent to:
ifppp7.heart
🏆For all children and adolescence (<18 years) with history of hospital admission!
🆔@HealthAndArt
🆔@usern_net
Role of Toll‐like receptors in the pathogenesis of COVID‐19
New Paper on COVID-19 by USERN Interest Group
🌀The exact pathogenesis of SARS‐CoV‐2 and role of each component of innate and adaptive immune system is still unknown.
🌀Toll‐like receptors (TLR) play an important role in recognition of viral particles and activation of innate immune system. Activation of TLR pathways lead to secretion of pro‐inflammatory cytokines
🌀TLRs could be a potential target in controlling the infection in early stages of disease and production of vaccine against SARS‐CoV‐2.
Source: https://doi.org/10.1002/jmv.26826
🌐 https://usern.tums.ac.ir/Group/Info/NIIMA
✉️ niima.usern@gmail.com
@niima_usern
❄️Winter Research Week 2021
❄️Hybrid method (in-peron and virtual)
▫️Scientific Writing, by Dr. Nima Rezaei
▫️Submission and Journal Selection, by Dr. Nima Rezaei
▫️Introduction to Basic Statistics, by Dr. Amene Saghazadeh
▫️Systematic Review, by Dr. Amene Saghazadeh
▫️Meta-Analysis, by Dr. Amene Saghazadeh
▫️Publishing Books with International Publishers, by Dr. Nima Rezaei
🗓February 27th to March 4th
🕰15:00 to 19:00
🌀For registration and more information, please click/tap here.
❌Registration deadline: February 19th
📧researchweek.usern@gmail.com
@usern_net
@niima_usern
@srmeg_usern
@nini_usern
@cip_usern
Adherence of the General Public to Self-Protection Guidelines During the COVID-19 Pandemic
New Paper on COVID-19 by USERN Interest Group
🌀In this cross-sectional study, we investigated adherence of the general public to use of PPE and their knowledge regarding the rationale behind their use.
🌀We conclude that education is an important aspect in containing the COVID-19 pandemic, as it directly increases adherence of the general public to protective measures.
Source: http://dx.doi.org/10.1017/dmp.2020.445
🔴Join the winter workshops: Registration
🌐 https://usern.tums.ac.ir/Group/Info/NIIMA
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@niima_usern
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COVID-19 infection and stroke risk
New Paper on COVID-19 by USERN Interest Group
🌀SARS-CoV-2 can exhibit neurotropic properties and may also cause neurological diseases, including epileptic seizures, cerebrovascular accident, Guillian barre syndrome, acute transverse myelitis, and acute encephalitis.
🌀In this study, we discuss stroke as a complication of the new coronavirus and its possible mechanisms of damage.
Source: https://doi.org/10.1515/revneuro-2020-0066
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List of USERN Publications on COVID-19 during January 2021
COVID-19 in patients with cancer: Risks and precautions
Razavi A, Hamblin MR, Rezaei N. Am J Emerg Med.
https://doi.org/10.1016/j.ajem.2021.01.067
Role of Toll-like receptors in the pathogenesis of COVID-19
Khanmohammadi S, Rezaei N. J Med Virol.
https://doi.org/10.1002/jmv.26826
The Overlap between Genetic Susceptibility to COVID-19 and Skin Diseases
Jabalameli N, Rajabi F, Firooz A, Rezaei N. Immunol Invest.
https://doi.org/10.1080/08820139.2021.1876086
The prevalence of post-traumatic stress disorder related symptoms in Coronavirus outbreaks: A systematic-review and meta-analysis
Salehi M, Amanat M, Mohammadi M, et al. J Affect Disord.
https://doi.org/10.1016/j.jad.2020.12.188
Drug-drug interactions with candidate medications used for COVID-19 treatment: An overview.
Rezaee H, Pourkarim F, Pourtaghi-Anvarian S, Entezari-Maleki T, Asvadi-Kermani T, Nouri-Vaskeh M. Pharmacol Res Perspect.
https://doi.org/10.1002/prp2.705
Critical roles of TLRs on the polarization of mesenchymal stem cells for cell therapy of viral infections: a notice for COVID-19 treatment
Gholizadeh-Ghaleh Aziz S, Alipour S, Ranjbarvan P, Azari A, Babaei G, Golchin A. Comp Clin Path.
https://doi.org/10.1007/s00580-021-03209-0
Stem Cell Therapy Potency in Personalizing Severe COVID-19 Treatment
Basiri A, Mansouri F, Azari A, et al. Stem Cell Rev Rep.
https://doi.org/10.1007/s12015-020-10110-w
Anti-inflammatory potential of Quercetin in COVID-19 treatment.
Saeedi-Boroujeni A, Mahmoudian-Sani MR. J Inflamm (Lond).
https://doi.org/10.1186/s12950-021-00268-6
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2
Rahmani A, Baee M, Saleki K, Moradi S, Nouri HR. J Biomol Struct Dyn.
https://doi.org/10.1080/07391102.2021.1876774
Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration
Dolatshahi M, Sabahi M, Aarabi MH. Mol Neurobiol.
https://doi.org/10.1007/s12035-020-02236-2
The Potential Role of Photobiomodulation in Long COVID-19 Patients Rehabilitation.
Fekrazad R, Fekrazad S. Photobiomodul Photomed Laser Surg.
https://doi.org/10.1089/photob.2020.4984
COVID-19 Pandemic Is a Call to Search for Alternative Protein Sources as Food and Feed: A Review of Possibilities.
Rzymski P, Kulus M, Jankowski M, et al. Nutrients.
https://doi.org/10.3390/nu13010150
Chloroquine/hydroxychloroquine: an inflammasome inhibitor in severe COVID-19?
Bahadoram M, Keikhaei B, Saeedi-Boroujeni A, Mahmoudian-Sani MR. Naunyn Schmiedebergs Arch Pharmacol.
https://doi.org/10.1007/s00210-020-02034-6
The dilemma of herd immunity for COVID-19
Nejadghaderi SA, Safiri S. J Med Virol.
https://doi.org/10.1002/jmv.26768
Epicardial adipose tissue, inflammatory biomarkers and COVID-19: Is there a possible relationship?.
Abrishami A, Eslami V, Baharvand Z, et al. Int Immunopharmacol.
https://doi.org/10.1016/j.intimp.2020.107174
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❄️USERN proudly presents:
Publishing Books with International Publishers Workshop
🔹Instructor: Prof. Nima Rezaei
🔹Special supporter: Springer publisher
🏆 Second Springer's award to the best participant of this workshop:
"From Research to Manuscript" book
🔹March 4th, 2021 (15:00 to 19:00)
🔻Limited seats.
🔻For registration and more information click/tap here.
📧researchweek.usern@gmail.com
@usern_net
@niima_usern
@srmeg_usern
@nini_usern
@cip_usern
List of USERN Publications on COVID-19 during December 2020
Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients.
Peymani P, Dehesh T, Aligolighasemabadi F, et al. Transl Med Commun.
https://doi.org/10.1186/s41231-021-00082-5
Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.
Hassan SS, Ghosh S, Attrish D, et al. Molecules.
https://doi.org/10.3390/molecules25245906
The immunology of SARS-CoV-2 infection, the potential antibody based treatments and vaccination strategies.
Payandeh Z, Mohammadkhani N, Nabi Afjadi M, et al. Expert Rev Anti Infect Ther.
https://doi.org/10.1080/14787210.2020.1863144
Dysregulation of the Immune Response in COVID-19
Khosroshahi LM, Rezaei N. Cell Biol Int.
https://doi.org/10.1002/cbin.11517
Serological tests for COVID-19: Potential opportunities
Tantuoyir MM, Rezaei N. Cell Biol Int.
https://doi.org/10.1002/cbin.11516
The structural basis of accelerated host cell entry by SARS-CoV-2
Seyran M, Takayama K, Uversky VN, et al. FEBS J.
https://doi.org/10.1111/febs.15651
Hydroxychloroquine in the COVID-19 pandemic era: in pursuit of a rational use for prophylaxis of SARS-CoV-2 infection.
Infante M, Ricordi C, Alejandro R, Caprio M, Fabbri A. Expert Rev Anti Infect Ther.
https://doi.org/10.1080/14787210.2020.1799785
Microfluidic devices for detection of RNA viruses.
Basiri A, Heidari A, Nadi MF, et al. Rev Med Virol.
https://doi.org/10.1002/rmv.2154
The possible double-edged sword effects of vitamin D on COVID-19: A hypothesis.
Shojaeefar E, Malih N, Rezaei N. Cell Biol Int.
https://doi.org/10.1002/cbin.11469
Fecal microbiota transplantation for COVID-19; a potential emerging treatment strategy
Nejadghaderi SA, Nazemalhosseini-Mojarad E, Asadzadeh Aghdaei H. Med Hypotheses.
https://doi.org/10.1016/j.mehy.2020.110476
When silence goes viral, Africa sneezes! A perspective on Africa's subdued research response to COVID-19 and a call for local scientific evidence
Gwenzi W, Rzymski P. Environ Res.
https://doi.org/10.1016/j.envres.2020.110637
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Inborn Errors of Immunity
📘 Editors:
Aghamohammadi, Asghar
Abolhassani, Hassan
Rezaei, Nima
Yazdani, Reza
📘 ISBN: 9780128210284
📘 Publisher: Elsevier
📘 A New Book by USERN Interest Group
📘 more information: https://www.elsevier.com/books/inborn-errors-of-immunity/aghamohammadi/978-0-12-821028-4
@niima_usern
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🔻6th Primary Immunodeficiency Spring School: A Junior Talk!
🗓 April 26-27, 2021
🔹Organized by the Research Center for Immunodeficiencies (RCID) and the Universal Scientific Education and Research Network (USERN)
🔸Abstract Submission & Registration:
https://b2n.ir/j52628
⏳Deadline for Abstract Submission:
March 1, 2021
🌐More Info:
http://rcidcong.tums.ac.ir/
📩Contact Us:
Info.rcidcong@gmail.com
@RCIDtums
@usern_net
Immune Checkpoint Inhibition in COVID-19: Risks and Benefits
New Paper on COVID-19 by USERN Interest Group
🌀The immunomodulatory effects of ICI can modify the patients’ immune system function in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
🌀There is controversy whether the severity of COVID-19 in cancer patients who previously received ICI compared to other patients with cancer is increased. There is evidence that the upregulation of immune checkpoint molecules on T cells, lymphopenia, and inflammatory cytokine secretion are associated with the severity of COVID-19 symptoms.
🌀ICI may also increase the risk of cytokine release syndrome. ICI can be considered not only as cancer immunotherapy but also as immunotherapy in COVID-19. More studies are needed to assess the safety of ICI in COVID-19 patients with or without cancer.
Source: https://doi.org/10.1080/14712598.2021.1887131
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Primary Immunodeficiency Diseases
🔹Prof. Nima Rezaei
🔹Approach to Inborn Errors of Immunity
▫️Participants can watch the LIVE stream from:
alerjim.tv
@niima_usern
@usern_net
🔻12th International Congress on Immunodeficiency Diseases (ICID)
🎧 Virtual Congress
🗓 April 26-27, 2021
🔹Organized by the Research Center for Immunodeficiencies (RCID)
🔸Abstract Submission & Registration:
https://b2n.ir/542985
⏳Deadline for Abstract Submission:
March 1, 2021
🌐More Info:
http://rcidcong.tums.ac.ir/
📩Contact Us:
info.rcidcong@gmail.com
@RCIDtums
@usern_net
Primary Immunodeficiency Diseases
🔹Prof. Nima Rezaei
🔹Approach to Inborn Errors of Immunity
🔹8 PM (Tehran Time)
▫️Participants can watch the stream from:
alerjim.tv
@niima_usern
@usern_net
Nasopharyngeal structure development in patients with cleft palate who underwent repair surgery
New Paper by USERN Interest Group
🌀This study was conducted on 64 non-syndromic CP patients who underwent repair surgery and 23 non-cleft subjects as controls.
🌀Patients with repaired CP had downward deviated posterior maxilla, more linear growth in cranial-maxillary dimension and larger area compared to normal subjects.
🌀Among CP subtypes, a balanced growth was observed among repaired UCLP and BCLP patients, suggesting that with appropriate repaired surgery, normal development of the NP region could be expected in these subtypes.
🔹Source: https://doi.org/10.1016/j.jormas.2021.01.008
🌐 https://usern.tums.ac.ir/Group/Info/NIIMA
✉️ niima.usern@gmail.com
@niima_usern
The 5th Primary Immunodeficiencies Congress (IPIC)
▫️November 3-5, 2021
▫️Berlin, Germany
▫️Registration and more information:
https://ipic2021.com/
@niima_usern
Potential treatment of Parkinson’s disease using new-generation carbon nanotubes: a biomolecular in silico study
New Paper by USERN Interest Group
🌀The inhibitory effect of doped carbon nanotubes (CNTs) on amyloid aggregation was studied.
🌀Doped-CNTs, especially phosphorus-doped carbon nanotube could effectively prevent α-synuclein amyloid formation, thus, it could be considered as a potential treatment for Parkinson’s disease.
Source: https://doi.org/10.2217/nnm-2020-0372
🌐 https://usern.tums.ac.ir/Group/Info/NIIMA
✉️ niima.usern@gmail.com
@niima_usern
Every Week, One UQR
✔️This week’s theme:
“Will AI save the humanity?”
💢Press the link below to read it:
https://bit.ly/36kAEG6
#UQR
@usern_net
@niima_usern