SRMEG

01 Jan 2021 12:17

✨معرفی برترین اینترست گروپ های یوسرن در سال ۲۰۲۰

💫Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA)

💫Cancer Immunology Project (CIP)

💫Systematic Review and Meta-analysis Expert Group (SRMEG)

💫Universal Council of Epidemiology (UCE)

💫ImmunologyToday


📌لینک اسکای‌ روم:

https://www.skyroom.online/ch/tums2/usern

📲 لایو در صفحه‌ی اینستاگرام یوسرن:

https://instagram.com/usern_net?igshid=1r919etejyeqe

@usern_net

SRMEG

29 Oct 2020 18:39

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

New paper on COVID-19 by USERN interest groups

🌀Covid-19 outbreak creates global panic across the continents, as people from almost all countries and territories have been affected by this highly contagious viral disease.

🌀We have proposed two novel drug targets, Furin and TMPRSS2, as Covid-19 treatment strategy. 

🌀We have highlighted this target-oriented novel drug delivery strategy, based on their pathophysiological implication on SARS-CoV-2 infection.

🌀An earlier study suggested that Furin and TMPRSS2 knockout mice had reduced level of viral load and a lower degree of organ damage such as the lung. 

🌀Furin and TMPRSS2 receptor may initiate to express and activate for processing the virus to cause cellular infection by replication within the host cell.

Source: https://doi.org/10.1016/j.phymed.2020.153396

#Paper
#COVID19
#USERN

@niima_usern
@usern_net

SRMEG

26 Oct 2020 12:04

Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis

New paper on COVID-19 by USERN interest groups

🌀High rate of cardiovascular disease (CVD) have been reported among patients with novel coronavirus disease (COVID-19). Meanwhile there were controversies among different studies about CVD burden in COVID-19 patients.

🌀Hence, we aimed to study CVD burden among COVID-19 patients, using a systematic review and meta-analysis.

🌀Fifty-six studies entered into meta-analysis for ICU admission and mortality outcome and 198 papers for descriptive outcomes, including 159,698 COVID-19 patients.

🌀Results of meta-analysis indicated that acute cardiac injury, hypertension, heart Failure, arrhythmia, coronary artery disease, and cardiovascular disease, and hypertension were also significantly associated with ICU admission in COVID-19 patients.

Source: https://doi.org/10.1016/j.ajem.2020.10.022

#Paper
#COVID19
#USERN

@niima_usern
@usern_net

SRMEG

23 Oct 2020 18:27

Death due to COVID-19 in an Infant with Combined Immunodeficiencies

New paper on COVID-19 by USERN interest group

🌀Novel coronavirus disease 2019 (COVID-19) has affected millions of people, which led to death especially in older cases with underlying diseases.

🌀Meanwhile pediatric patients with inherited defects of T cell should potentially be prone to viral diseases.

🌀Herein, we report an infant with combined immunodeficiency who died because of COVID-19.

Source: https://doi.org/10.2174/1871530320666201021142313

#Paper
#COVID19
#USERN

@niima_usern
@usern_net

SRMEG

22 Oct 2020 18:14

Funnel plots in meta-analysis

A funnel plot that shows publication bias.

Source: https://journals.sagepub.com/doi/pdf/10.1177/1536867X0400400204

#Funnel_plot
#Publication_bias

SRMEG

20 Oct 2020 17:36

Meta-analysis results are unlikely to be biased by differences in variance and replication between ecological lab and field studies

Box and whisker plots that show mean effect sizes and commonly used in ecological and evolutionary meta-analysis.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/oik.01288

#Meta_analysis
#Box_and_whisker

SRMEG

16 Oct 2020 19:46

Trial sequential boundaries for cumulative meta-analyses

A forest plot that shows a cumulative meta-analysis where effect sizes are meta-analyzed cumulatively in a chronological order, thus, showing a temporal trend and convergence of effect sizes across studies.

Source: https://journals.sagepub.com/doi/pdf/10.1177/1536867X1301300106

#Forest_plot
#Cumulative_meta_analysis

SRMEG

14 Oct 2020 19:30

Meta-Analysis: Fixed effect vs. random effects

A forest plot that shows overall means based on a fixed-effect model and random-effects model. It is commonly used in medical meta-analyses.

Source: https://www.meta-analysis.com/downloads/Meta-analysis%20fixed%20effect%20vs%20random%20effects%20072607.pdf

#Meta_analysis
#Fixed_effect
#Random_effects
#Forest_plot

SRMEG

12 Oct 2020 20:00

Borrow crisis tactics to get COVID-19 supplies to where they are needed

Robert B. Wilson is one of the 2 Stanford economists who have won the 2020 Nobel Prize in Economy for their contribution to understanding 'how auctions work'.

This directs you to one of his recent comments on COVID.

#Economy
#COVID
#Auction
#Universe

SRMEG

11 Oct 2020 21:32

Dietary inflammatory index and depression: a meta-analysis

Low-grade chronic inflammation has been linked to the pathophysiology of depression.

This is a systematic review and meta-analysis of 6 studies that suggests that pro-inflammatory diet estimated by a higher DII score is independently associated with an increased risk of depression, particularly in women. However, more well-designed studies are needed to evaluate whether an anti-inflammatory diet can reduce the risk of depression.

#DII
#Diet
#Depression
#Nutrition
#Meta_analysis

SRMEG

11 Oct 2020 20:30

Dietary Inflammatory Index and Cardiovascular Risk and Mortality—A Meta-Analysis

Diet and chronic inflammation have been suggested to be risk factors in the development of cardiovascular disease (CVD) and related mortality.

This is a systematic review and meta-analysis of 14 studies that supports the notion that a pro-inflammatory diet is associated with increased risk of CVD and CVD mortality.

#DII
#Diet
#Nutrition
#Cardiovascular
#Meta_analysis

SRMEG

09 Oct 2020 19:30

The United Nations World Food Programme (WFP) is the winner of the 2020 Nobel Prize in Peace for its efforts to combat hunger as a weapon of war and improve conditions for peace.

The UN World Food Programme is funded in 1961 and works in over 80 countries.
This directs you to UN World Food Programme.

#Peace
#Nutrition
#World
#Lessons_to_be_learned

SRMEG

08 Oct 2020 19:30

Louise Glück is the winner of the 2020 Nobel Prize in Literature for her ‘unmistakable poetic voice’.

Louise Glück in her lyric, The Wild Iris, imagines the self as unruly, as crossing the border between the human and the not human, as under construction, and in a state of becoming.

The word “iris” in Latin means “rainbow”; it is also the rainbow goddess “whose prism-bridge connects sky and earth.”

This directs you to Louise Glück's Classic Poetry Series.
This is a thematic introduction to Louise Glück's poetry.

#Literature
#Borderless
#Universal

SRMEG

07 Oct 2020 19:30

The Biology of CRISPR-Cas: Backward and Forward

Emmanuelle Charpentier is one of the two winners of the 2020 Nobel Prize in Chemistry for her work that led to the development of revolutionary CRISPR gene editing.

This directs you to one of her recent reviews of CRISPR biology.

#Chemistry
#CRISPR
#Universe
#Lessons_to_be_learned

SRMEG

06 Oct 2020 20:00

Testing General Relativity with the Shadow Size of Sgr A∗

Reinhard Genzel is one of the three winners of the 2020 Nobel Prize in Physics for his work that led to the discovery of black holes that revealed the darkest secrets of the universe.

This directs you to one of his recent original contributions to general relativity.

#Physics
#Universe
#Lessons_to_be_learned

SRMEG

24 Nov 2020 16:38

Human coronaviruses SARS-CoV, MERS-CoV, and SARS-CoV-2 in children

New paper on COVID-19 by USERN interest group

🌀COVID-19 has caused an epidemic with high mortality and morbidity since December 2019, in Wuhan, China.

🌀The pediatric population is just as likely as adults to become infected with COVID-19.

🌀The pediatric population may be asymptotic or have milder symptoms than adults; they can be potential carriers of the disease.

🌀COVID-19 mainly cause fever, respiratory symptoms, and other flu-like manifestations in pediatrics.

🌀Public education as well as isolation of the contaminated people, should be taken into consideration.

Source: https://www.sciencedirect.com/science/article/pii/S088259632030631X

#Paper
#COVID19
#USERN

@niima_usern
@srmeg_usern
@usern_net

SRMEG

29 Oct 2020 18:39

Emerging Standards and the Hybrid Model for Organizing Scientific Events During and After The COVID-19 Pandemic

The paper by USERN 2020 speakers!

🌀During COVID19 pandemic, activities requiring human gatherings have either been postponed, cancelled, or held completely virtually.

🌀To supplement lack of in-person contact, people have increasingly turned to virtual settings on-line. However, emerging online technologies cannot fully replace in-person scientific events.

🌀To continue such activities, a hybrid model for scientific events could be a solution offering both in-person and virtual components. While participants can freely choose type of their participation.

🌀This new way of interaction between scholars can be considered as a part of a resilience system which was neglected previously and should become a part of the routine practice in scientific community.

Source: https://doi.org/10.1017/dmp.2020.406

#usern2020
@niima_usern
@usern_net
@usern2020congress

SRMEG

25 Oct 2020 16:31

Meta-analysis and the science of research synthesis

Meta-analysis, the quantitative synthesis of research results first introduced in the 1970s, has helped to establish evidence-based practice, resolve seemingly contradictory results, and has had a revolutionary
impact on many scientific fields.

The implementation of meta-analysis has engendered various criticisms and controversies, including mixing apples and oranges, and the proper relationship between primary researchers and research synthesists.

This is a review of the accomplishments, limitations, recent advances, and the direction of future developments in the field of research synthesis.

#Data_synthesis
#Meta_analysis
#Science

SRMEG

22 Oct 2020 20:24

Viewpoint: Origin of SARS-CoV-2

New paper on COVID-19 by USERN interest group

🌀The origin of SARS-CoV-2 virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist.

🌀SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor.

🌀The SARS-CoV-2 does not appear to present a mutational “hot spot” as only the D614G mutation has been identified from clinical isolates.

🌀It can be hypothesized that the SARS-CoV-2 genome has adapted during human-to-human transmission.

Source: https://doi.org/10.3390/v12111203

#Paper
#COVID19
#USERN

@niima_usern
@usern_net

SRMEG

21 Oct 2020 19:55

Meta-regression in Stata

A bubble plot that shows a meta-regression analysis where the size of the bubble reflect study sample size

Source: https://journals.sagepub.com/doi/pdf/10.1177/1536867X0800800403

#Bubble_plot
#Meta_regression

SRMEG

18 Oct 2020 20:24

The above figure: What is it called?
anonymous poll

Box and whisker plots that show mean effect sizes – 9
👍👍👍👍👍👍👍 90%

A forest plot that shows overall means – 1
👍 10%

A forest plot that shows a cumulative meta-analysis
▫️ 0%

A bubble plot that shows a meta-regression analysis
▫️ 0%

A funnel plot that shows funnel asymmetry
▫️ 0%

👥 10 people voted so far. Poll closed.

SRMEG

15 Oct 2020 19:30

The above figure: What is it called?
anonymous poll

Box and whisker plots that show mean effect sizes – 4
👍👍👍👍👍👍👍 44%

A forest plot that shows a cumulative meta-analysis – 3
👍👍👍👍👍 33%

A bubble plot that shows a meta-regression analysis – 2
👍👍👍👍 22%

A forest plot that shows overall means
▫️ 0%

A funnel plot that shows funnel asymmetry
▫️ 0%

👥 9 people voted so far. Poll closed.

SRMEG

13 Oct 2020 21:09

The above figure: What is it called?
anonymous poll

A forest plot that shows overall means – 8
👍👍👍👍👍👍👍 62%

A forest plot that shows a cumulative meta-analysis – 3
👍👍👍 23%

A bubble plot that shows a meta-regression analysis – 2
👍👍 15%

A funnel plot that shows funnel asymmetry
▫️ 0%

Box and whisker plots that show mean effect sizes
▫️ 0%

👥 13 people voted so far. Poll closed.

SRMEG

12 Oct 2020 19:30

How Artificial Intelligence and Machine Learning Can Impact Market Design

Paul R. Milgrom is one of the 2 Stanford economists who have won the 2020 Nobel Prize in Economy for their contribution to understanding 'how auctions work'.

This directs you to one of his recent reviews of artificial intelligence.

#Economy
#AI
#Auction
#Universe

SRMEG

11 Oct 2020 21:00

Meta-analysis of the association between the dietary inflammatory index (DII) and breast cancer risk

Breast cancer is the leading cause of cancer deaths in women worldwide, representing 25% of all cancer cases. Chronic inflammation is important in the carcinogenesis process.

This is a systematic review and meta-analysis of 7 studies that supports the notion that pro-inflammatory diets (higher DII scores) are associated with increased breast cancer incidence. However, the research is not about significant associations but about moderate effect sizes.

#DII
#Diet
#Nutrition
#Cancer
#Meta_analysis

SRMEG

09 Oct 2020 21:43

✨پنجمین کنگره یوسرن در سال ۲۰۲۰ به میزبانی ایران✨

✅ به ما بپيونديد در لايو اينستاگرام در روز يكشنبه ٢٠ مهر ساعت ١٩
🔹 جلسه لايو اينستاگرام جهت توضيح برنامه هاي كنگره از جمله برنامه سالنها و سخنرانيها، پاسخ به سوالات متداول و سوالات شما شركت كنندگان گرامى

http://instagram.com/usern_net

#USERN2020

SRMEG

08 Oct 2020 20:00

USERN on the Previous 6 Months of the COVID-19 Pandemic

Prof. Nima Rezaei, the Professor of Immunology at Tehran University of Medical Sciences and the Founding President of USERN, presents what actions USERN has taken in response to the COVID-19 pandemic over the last six months

#COVID19

@niima_usern
@srmeg_usern
@usern_net

SRMEG

07 Oct 2020 20:00

The Promise and Challenge of Therapeutic Genome Editing

Jennifer A. Doudna is one of the two winners of the 2020 Nobel Prize in Chemistry for her work that led to the development of revolutionary CRISPR gene editing.

This directs you to one of her recent reviews of genome editing, where she notes that "Genome editing is—or will soon be—in the clinic for several diseases, with more applications under development."

#Chemistry
#CRISPR
#Universe
#Lessons_to_be_learned

SRMEG

06 Oct 2020 20:30

A population of dust-enshrouded objects orbiting the Galactic black hole

Andrea Ghez is the youngest (55 yrs) of the three winners of the 2020 Nobel Prize in Physics for her work that led to the discovery of black holes that revealed the darkest secrets of the universe.

This directs you to one of her recent original contributions to black hole.

#Physics
#Universe
#Lessons_to_be_learned

SRMEG

06 Oct 2020 19:30

Consciousness in the universe: a review of the 'Orch OR' theory

Roger Penrose is one of the three winners of the 2020 Nobel Prize in Physics for his work that led to the discovery of black holes that revealed the darkest secrets of the universe.

This directs you to one of his reviews of consciousness in the universe.

#Physics
#Universe
#Mind
#Consciousness
#Lessons_to_be_learned