Internal Medicine
10 September 2025 16:35
💢 Nice graphic on hemodialysis and peritoneal dialysis
🔗 JAMA 2024;332;(18):1559-1573.
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Internal Medicine
05 September 2025 00:26
💢 Get screened for colon cancer
Early screening for Colon Cancer has become more common in recent years. Joffrey Kopin, MD, joined Jon Hansen to discuss the importance of early screening and more. Listen now:
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http://wgnradio.com/health/dr-jeffrey-kopin-get-screened-for-colon-cancer
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Internal Medicine
03 September 2025 23:37
💢 Powerful new painkiller ADRIANA shows promise in ending opioid dependence
https://www.sciencedaily.com/releases/2025/09/250901104649.htm
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Internal Medicine
01 September 2025 13:15
💢 Rare Liver Damage Linked to Vinegar in 60-Year-Old Patient
عارضه کبدی سرکه سیب
https://www.medscape.com/viewarticle/rare-liver-damage-linked-vinegar-60-year-old-patient-2025a1000mzf
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Internal Medicine
31 August 2025 20:52
💢 Glossitis as a Diagnostic Clue for Pernicious Anemia
62-year-old man presented with a 7-month history of generalized fatigue and exertional dyspnea, along with bilateral lower limb edema that had developed 1 week prior to admission. Despite a well-balanced diet, he experienced unintentional 10kg weight loss over the past year. He had no significant medical history and used no regular medications except vitamin supplements.
On physical examination, pallor of the palpebral conjunctiva and jaundice of the bulbar conjunctiva were observed. A smooth tongue with atrophy of lingual papillae was noted (Figure). Pitting edema was present in both lower legs. Laboratory investigations revealed macrocytic anemia (Hb 4.1 g/dL, MCV 113.5 fL) and thrombocytopenia (platelet count 36,000/μL). LDH levels were elevated at 1431 U/L, with increased indirect bilirubin (1.2 mg/dL). Peripheral blood smear showed fragmented red blood cells. Chest computed tomography demonstrated evidence of pulmonary congestion.
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Internal Medicine
29 August 2025 19:13
2025 ACC Scientific Statement on the Management of Obesity in Adults With Heart Failure
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Internal Medicine
29 August 2025 16:27
💢 Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Collagen supplements have not proven effective for aging skin when only high-quality and independently funded studies are considered; observed benefits are mostly limited to studies funded by pharmaceutical companies and those of lower quality.
Key Findings
- Collagen supplements were associated with improved skin hydration, elasticity, and wrinkles when analyzing all 23 RCTs together.
- However, in studies not funded by pharmaceutical companies, collagen supplements showed no significant benefits for hydration, elasticity, or wrinkle improvement.
- In studies of high methodological quality, no significant effect was observed in any category.
- Low-quality studies showed a small improvement in skin elasticity, but not in other skin parameters.
Funding and Bias
- Studies funded by pharmaceutical companies consistently reported significant improvements in skin parameters.
- This suggests potential bias in commercially funded studies.
Clinical Implications
- No solid clinical evidence currently supports the use of collagen supplements for preventing or treating skin aging.
- Recommendations for collagen supplementation for skin health should be made cautiously, especially considering study quality and funding bias.
📎 Link
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Internal Medicine
29 August 2025 08:44
2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease
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Internal Medicine
29 August 2025 08:44
2025 ESC Guidelines for the management of myocarditis and pericarditis
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Internal Medicine
29 August 2025 08:44
2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias
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Internal Medicine
27 August 2025 17:27
💢 Updated Guidelines From the Society of Critical Care Medicine Strongly Recommend Steroids for Hospitalized Adults With Severe CAP
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Internal Medicine
26 August 2025 22:39
💢 Rapidly Progressing Facial Rash
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Internal Medicine
23 August 2025 10:52
💢 Snowman Sign in Pituitary Macroadenoma
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Internal Medicine
22 August 2025 18:03
💢 Good News on GLP-1s and Cancer Risk, With One Exception
A large retrospective study found that GLP-1 receptor agonist (GLP-1RA) use for weight loss is linked to a 17% lower overall cancer risk compared to non-users, with follow-up ranging from 1 to 11 years.
Statistically significant cancer risk reductions were observed for endometrial cancer (HR 0.75), ovarian cancer (HR 0.53), and meningioma (HR 0.69), all hormone-sensitive or metabolism-related cancers.
Most other obesity-associated cancers, including colorectal, breast, prostate, and lung cancers, showed a trend toward reduced risk in GLP-1RA users, though these findings were not statistically significant.
The only exception was kidney cancer, which had a non-significant increased risk (HR 1.38) among GLP-1RA users, especially in patients under 65 and those who were overweight but not obese, requiring further investigation.
These results support existing evidence from bariatric surgery studies and prior research linking weight loss and cancer risk reduction, highlighting obesity management as a key cancer prevention strategy.
Limitations include the study’s retrospective observational design, lack of longitudinal BMI and glycemic control data, and reliance on electronic health records, meaning causality cannot be confirmed.
The findings underscore the need for prospective randomized trials to clarify whether GLP-1 agonists directly reduce cancer risk or if benefits stem from weight loss and metabolic improvements.
Given that over 137 million people in the U.S. are eligible for GLP-1RA therapy, even modest changes in cancer risk could have significant public health implications.
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