Internal Medicine (5.4k)

23 Feb 2024 14:05

💢 Rusfertide for Control of Erythrocytosis in Polycythemia Vera


🆔 @Internalmed
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Internal Medicine (5.4k)

22 Feb 2024 14:45

/channel/+jb8aGHkDgq80MDMy

Internal Medicine (5.4k)

20 Feb 2024 08:58

💢 GLP-1s associated with reduced risk for depression, anxiety in patients with diabetes

👇
https://www.healio.com/news/primary-care/20240219/glp1s-associated-with-reduced-risk-for-depression-anxiety-in-patients-with-diabetes


🆔 @Internalmed
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Internal Medicine (5.4k)

19 Feb 2024 05:32

💢 Clinical Manifestations of Behçet’s Syndrome.

Shown are the typical features of Behçet’s syndrome, including an oral ulcer (Panel A); a papulopustular lesion (Panel B); erythema nodosum (Panel C); capillary impairment and vascular leakage on retinal fluorescein angiography (Panel D); a brain-stem inflammatory lesion on a T2-weighted axial magnetic resonance imaging sequence, with an edematous, protuberant FLAIR (fluid attenuated inversion recovery) hypersignal extending to the middle cerebellar peduncles and discrete hypertrophy (Panel E); and aneurysmal dilatation of a pulmonary-artery branch (Panel F, arrowhead).


🆔 @Internalmed
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Internal Medicine (5.4k)

16 Feb 2024 17:26

💢 Postinfectious cough in adults


🆔 @Internalmed
.

Internal Medicine (5.4k)

12 Feb 2024 22:10

📍عصرانه این هفته:
      تنش، اضطراب و دلهره
در زندگی روزمره
📍با حضور:
      دکتر مهدیه معین الغربایی
عضو هیات علمی دانشگاه علوم پزشکی تهران

🗓 جمعه بیست و هفتم بهمن ماه
⏰ ساعت پنج و نیم عصر

دنیای پر از تنشی داریم.
همه ما احساس اضطراب رو تجربه کردیم.
گاهی شدیدا نگران وضع خودمان، عزیزانمان و حتی جامعه و دنیایمان می‌شویم.
چقدر از این احساس‌ها به جا هستند؟
با آنها چه باید کرد؟
این هفته، در این مورد از دکتر معین الغربایی خواهیم آموخت.

🔗 لینک برنامه عصرانه
👈 در تقویم گوگل ثبت کنید

برنامه به صورت لایو در اینستاگرام هم پخش خواهد شد،
اما توصیه ما فعلا شرکت از طریق Google meet است.

شرکت برای عموم آزاد است.


🔥🔥در پادکست عصرانه صوت عصرانه های قبلی را گوش کنید🔥🔥


این پست را برای هر کسی که سلامتی‌اش برای شما مهم است ارسال کنید.

#آگاهتر_سالمتر
#عصرانه
#بارش


🌧 بارش، گروهی برای آموزش

.

Internal Medicine (5.4k)

11 Feb 2024 18:54

💢 دوز کم آسپیرین و پیشگیری از سرطان روده بزرگ

Low-dose aspirin and prevention of colorectal cancer: evidence from a nationwide registry-based cohort in Norway. Am J Gastroenterol. 2024 Feb 1

📊 مروری بر مطالعه:
محققان یک مطالعه کوهورت سراسری را در نروژ از سال 2004 تا 2018 انجام دادند تا ارتباط بین مصرف دوز پایین آسپیرین و خطر ابتلا به سرطان روده بزرگ (CRC) را بررسی کنند. آنها داده های ثبت ملی، از جمله نسخه های دارویی، بروز سرطان، و عوامل اجتماعی و جمعیت شناختی را تجزیه و تحلیل کردند.


🩺 یافته ها و نتایج:
از میان 2,186,390 نفر، 579,196 نفر (26.5%) از دوز پایین آسپیرین استفاده کردند و 38577 (1.8%) در طی یک پیگیری متوسط 10.9 ساله به CRC مبتلا شدند. این مطالعه نشان داد که مصرف فعلی آسپیرین در مقایسه با عدم استفاده از آن، با کاهش خطر ابتلا به CRC ارتباط دارد (HR=0.87; 95%CI: 0.84-0.90).
ارتباط بین مصرف آسپیرین و کاهش خطر CRC بر اساس مرحله سرطان متفاوت و برای CRC متاستاتیک (HR=0.79; 0.74-0.84) بیشتر از انواع غیرمتاستاتیک بود.


📉 مدت و تاثیر:
هر چه افراد مدت طولانی‌تر از آسپیرین استفاده کنند، خطر ابتلا به CRC کمتر می‌شود:
HR=0.91 (95% CI 0.86-0.95) for <3 years,
HR=0.85 (0.80-0.91) for 3-5 years, and
HR=0.84 (0.80-0.88) for ≥5 years, compared to never use.


💡 تحلیل:
دوز پایین آسپیرین از 1,073 مورد CRC در مدت مطالعه جلوگیری کرد. این یافته‌ها اثر محافظتی آسپیرین در برابر CRC را نشان می‌دهد و اطلاعات ارزشمندی را برای مداخلات بالینی پیشگیرانه ارائه می‌دهد. با این حال، شرایط و خطرات فردی باید قبل از شروع درمان با آسپیرین برای پیشگیری از CRC در نظر گرفته شود.


🆔 @GIJournalClub
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Internal Medicine (5.4k)

07 Feb 2024 13:22

💢بالاترین شیوع سیفلیس در ایالات‌متحده از ١٩۵٠ تا کنون

https://castbox.fm/vd/670909862


🆔 @Internalmed
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Internal Medicine (5.4k)

04 Feb 2024 18:42

💢 Risk for CKD, CVD Lower for Adults With Evidence of
Type 2 Diabetes Remission


📊 A recent study, published in Diabetologia, reveals that individuals showing evidence of remission from type 2 diabetes experience a significant reduction in the risks associated with chronic kidney disease (CKD) and cardiovascular disease (CVD). The study, led by Edward W. Gregg, Ph.D., from the Royal College of Surgeons of Ireland in Dublin, involved a multicenter randomized controlled trial comparing a 12-year intensive lifestyle intervention with diabetes support and education for long-term outcomes.

🩺 The incidence of CVD and CKD was compared among 4,402 and 4,132 participants based on the achievement and duration of diabetes remission. Cardiovascular disease incidence was defined broadly, including nonfatal acute myocardial infarction, stroke, admission for angina, or CVD death. High-risk or very high-risk CKD categories were determined using the Kidney Disease Improving Global Outcomes criteria.

📉 The results, after adjusting for various factors such as hemoglobin A1c, blood pressure, lipid levels, CVD history, diabetes duration, and intervention arm, showed that participants with evidence of any remission during follow-up had significantly reduced risks for CKD and the composite CVD measure (hazard ratios of 0.67 and 0.60, respectively). Interestingly, individuals with longer-term remission demonstrated the greatest magnitude of risk reduction.

🌟 Edward W. Gregg highlighted the study's significance, stating that it is the first intervention study linking remission with a reduction in diabetes-related complications. He expressed optimism, calling it encouraging news for those who can achieve remission from type 2 diabetes. Despite acknowledging the challenges of maintaining weight loss and remission, Gregg suggested that any success with remission is associated with later health benefits. The findings emphasize the potential positive impact of achieving remission on long-term health outcomes for individuals with type 2 diabetes.


🆔 @Internalmed
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Internal Medicine (5.4k)

04 Feb 2024 11:22

💢 گزارش جهانی جدید سرطان


📊 سازمان جهانی بهداشت (WHO) آخرین برآوردهای بار سرطان جهانی را در آستانه روز جهانی سرطان منتشر کرده است. آژانس بین المللی تحقیقات سرطان (IARC)، آژانس سرطان WHO، بار فزاینده سرطان و نیاز فوری به رسیدگی به نابرابری ها در سراسر جهان را برجسته می کند.

📈 در سال 2022، 20 میلیون مورد جدید سرطان، 9.7 میلیون مرگ و 53.5 میلیون بازمانده 5 ساله سرطان وجود داشت. نظرسنجی WHO نشان می دهد که اکثر کشورها به اندازه کافی خدمات سرطان و مراقبت های تسکینی اولویت دار را به عنوان بخشی از پوشش همگانی سلامت (UHC) تامین مالی نمی کنند.

🚨 تنها 39 درصد از کشورهای شرکت کننده اصول اولیه مدیریت سرطان را در بسته های مزایای سلامتی خود (HBP) پوشش دادند. سرطان‌های ریه، سینه و کولورکتال مجموعاً دو سوم موارد جدید و مرگ‌ومیرهای جهانی را در سال 2022 تشکیل می‌دهند.

🔍 سرطان ریه شایع ترین سرطان در سراسر جهان بوده و پس از آن سرطان سینه و کولورکتال قرار دارند. نابرابری های قابل توجهی بر اساس شاخص توسعه انسانی (HDI) به ویژه برای سرطان سینه یافت شد.

🌍 نظرسنجی جهانی نابرابری قابل توجهی را در خدمات سرطان نشان داد، به طوری که کشورهای کم درآمد در دسترسی به مراقبت های اولیه سرطان با چالش هایی مواجه بودند. WHO بر نیاز به سرمایه گذاری های عمده برای رسیدگی به نابرابری های جهانی در پیامدهای سرطان تاکید می کند.

📆 با نگاهی به آینده، بیش از 35 میلیون مورد جدید سرطان در سال 2050 پیش‌بینی می‌شود که نشان‌دهنده افزایش 77 درصدی نسبت به سال 2022 است. انتظار می‌رود کشورهای با HDI بالا بیشترین افزایش مطلق را تجربه کنند، اما کشورهای با HDI پایین و متوسط بیشترین افزایش نسبی را در بروز و مرگ و میر سرطان مشاهده خواهند کرد.


#روز_جهانی_سرطان
#سلامت_جهانی
#تحقیقات_سرطان


🆔 @hr1ghadam
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Internal Medicine (5.4k)

03 Feb 2024 04:41

How to interpret thyroid function tests?

Internal Medicine (5.4k)

31 Jan 2024 14:57

💢 OCD Tied to a Twofold Increased Risk for All-Cause Mortality

https://www.medscape.com/viewarticle/ocd-tied-twofold-increased-risk-all-cause-mortality-2024a1000250


🆔 @Internalmed
.

Internal Medicine (5.4k)

30 Jan 2024 13:32

💢 Death risk lower for adults with obesity who feel less isolated and lonely

https://www.healio.com/news/endocrinology/20240125/death-risk-lower-for-adults-with-obesity-who-feel-less-isolated-and-lonely


🆔 @Internalmed
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Internal Medicine (5.4k)

29 Jan 2024 18:20

💢 Healthy lifestyle paired with statins may boost life expectancy

https://www.healio.com/news/cardiology/20240126/healthy-lifestyle-paired-with-statins-may-boost-life-expectancy


🆔 @Internalmed
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Internal Medicine (5.4k)

28 Jan 2024 20:56

💢 Therapeutic Advances in Rheumatoid Arthritis


🆔 @Internalmed
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Internal Medicine (5.4k)

23 Feb 2024 12:36

💢 Chylothorax


🆔 @Internalmed
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Internal Medicine (5.4k)

20 Feb 2024 18:23

💢 Statins may lower risk for any dementia among adults with heart failure


https://www.healio.com/news/cardiology/20240220/statins-may-lower-risk-for-any-dementia-among-adults-with-heart-failure


🆔 @Internalmed
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Internal Medicine (5.4k)

19 Feb 2024 09:33

💢 Behçet’s Syndrome


🆔 @Internalmed
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Internal Medicine (5.4k)

18 Feb 2024 16:39

https://podcasts.apple.com/us/podcast/harrisons-podclass-internal-medicine-cases-and-board-prep/id1453765092?i=1000641230921


🆔 @Internalmed
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Internal Medicine (5.4k)

14 Feb 2024 15:00

💢 Type 2 diabetes remission more likely with gastric bypass vs. sleeve gastrectomy

https://www.healio.com/news/endocrinology/20240213/type-2-diabetes-remission-more-likely-with-gastric-bypass-vs-sleeve-gastrectomy


🆔 @Internalmed
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Internal Medicine (5.4k)

12 Feb 2024 17:30

💢 Spicy food consumption reduces the risk of ischemic stroke: a prospective study

British Journal of Nutrition. 2024 Jan 30:1-25.


📊 Previous studies suggested a link between consuming spicy food and reduced mortality from cardiovascular disease, yet the relationship with stroke types and dose-response remained unexplored.

🔍 The study involved 50,174 participants aged 30-79 years, collecting data on spicy food consumption through baseline surveys. Over a median 10.7-year follow-up, 3,967 strokes were recorded, including 3,494 ischemic strokes and 516 hemorrhagic strokes.

🌶 Compared to those who rarely consumed spicy food, participants consuming spicy food 1-5 days/week showed reduced risk of overall stroke and ischemic stroke.

⚖️ The analysis revealed a U-shaped dose-response relationship, indicating that moderate consumption of spicy food was associated with the lowest risk of ischemic stroke. Notably, obese participants consuming spicy food ≥3 days/week showed a notably reduced risk of ischemic stroke, suggesting a potential protective effect in this subgroup.

📑 While further research is needed to elucidate the underlying mechanisms and validate these findings in diverse populations, this study provides valuable insights into the role of spicy food in mitigating stroke risk.


🆔 @Internalmed
.

Internal Medicine (5.4k)

10 Feb 2024 20:29

Maximum recommended doses of statins in adults with chronic kidney disease according to estimated glomerular filtration rate (eGFR)

Internal Medicine (5.4k)

05 Feb 2024 12:20

💢 Five Things Clinicians Need to Know About Zoonotic Viral Spillover and Spillback

AMA Journal of Ethics


Since the 1990s, infectious diseases originating in animals have posed a significant threat to global health. Despite efforts, current surveillance and mitigation strategies have been criticized.

🦠 Lesson 1: Viruses Are Everywhere
The vast number of diverse viral threats, both externally and within the human body, highlights the remarkable effectiveness of the human immune system in preventing viral diseases.

🧪 Lesson 2: Diagnostic Challenges
Modern diagnostic tools, while sensitive and specific for known viruses, can miss clinically important viral infections. Delays and challenges in developing diagnostics for emerging viruses underscore the need for continuous improvement in laboratory diagnostic science.

🌍 Lesson 3: Viral Spillover Variability
An estimated 1.67 million undiscovered viruses are present in mammal and bird hosts. Detecting pathogens in early spillover stages requires specialized surveillance strategies and diagnostic approaches to prevent potential epidemics.

🔄 Lesson 4: Global Threat of Viral Spillback
Zoonotic viruses causing human diseases can spill over into other animal populations, mutate, and spill back, leading to additional outbreaks. Concerns about novel variants of SARS-CoV-2 in diverse animal hosts highlight the global and domestic public health threats posed by viral spillback events.

🩺 Lesson 5: Clinicians' Role and Responsibilities
Clinicians are urged to be knowledgeable and vigilant agents in detecting spillover events. Recognizing the limitations of current detection methods, clinicians should actively engage with public health officials and contribute to reporting networks to facilitate timely responses to potential outbreaks.

In conclusion, the article emphasizes the need for a comprehensive, multidisciplinary approach, incorporating One Health principles, to enhance the detection and response capabilities for emerging viral pathogens. Clinicians play a crucial role in this process, necessitating ongoing education and collaboration to effectively address the evolving landscape of viral zoonoses.


🆔 @Internalmed
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Internal Medicine (5.4k)

04 Feb 2024 16:51

💢 Once-Weekly Insulin Icodec Demonstrates Efficacious, Safe Glycemic Control

🗞️ Diabetes Obes Metab. Published online January 8, 2024. doi:10.1111/dom.15408



▫️Insulin icodec is a once-weekly insulin injection that can effectively control blood sugar levels in patients with type 2 diabetes.

▫️The results of a clinical trial demonstrated that once-weekly insulin icodec was comparable to daily insulin degludec in terms of glycemic control.

▫️Patients using once-weekly insulin icodec experienced a significant reduction in HbA1c levels, indicating improved long-term glucose control.

▫️The safety profile of once-weekly insulin icodec was similar to that of daily insulin degludec, with no significant differences in adverse events.

▫️This new insulin option offers convenience and of use for patients with type 2 diabetes, as it eliminates the need for daily injections and allows for weekly dosing.


🆔 @Internalmed
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Internal Medicine (5.4k)

03 Feb 2024 23:41

💢 Coffee Boosts Brain Function and Makes You Live Longer


While we always want to be careful of the risk of confusing correlation for causation, the volume and consistency of these studies is compelling. Here's a quick look back at a few of the most persuasive and interesting among them:

A double-blind study out of Johns Hopkins University a decade ago and published in the journal Nature Neuroscience found that giving study participants a 200-milligram caffeine tablet was correlated with better performance on memory tests. "We've always known that caffeine has cognitive-enhancing effects," said the lead author.

A massive study of nearly 500,000 British adults published in JAMA Internal Medicine found that those who drank at least two to three cups of coffee per day -- and as many as eight cups -- were "about 10 percent to 15 percent less likely to die" of any cause during the 10-year study period than those who didn't.

A study of the coffee habits of 12,583 people in the Journal of the American Medical Directors Association, found that those who drank four or more cups of coffee per day were doubly likely to avoid physically frailty into their 70s.

A Canadian study published in 2017 the journal Frontiers in Neuroscience found that phenylindanes, a chemical created during the coffee roasting process, seems to stop the buildup of two toxic proteins in the brain, which have been linked to Alzheimer's and Parkinsons's diseases. "Coffee consumption does seem to have some correlation to a decreased risk," said one of the study authors. "But we wanted to investigate why."

A study last year in the journal GeroScience found that mice who given trigonelline (TG), which is a plant alkaloid found in coffee, performed better in experiments testing their "acquiring, retaining, structuring, and applying information" abilities.

Another study, published in the Annals of Internal Medicine, examined the habits of nearly 350,000 cpeople, and found that the moderate to heavy coffee drinkers among them were 30 percent less likely to die of any cause during the study period than those who did not.

A study in which researchers were funded by the American Heart Association and the University of Colorado School of Medicine found that risk of heart failure or stroke went down 8 percent for each additional cup of coffee per day.

We can keep going -- and I'm sure I will, because as a copious coffee drinker myself, I'm always on the look for these kinds of studies.

As written in the free ebook, Neuroscience: 13 Ways to Train Your Brain for Life, sometimes the best health news is when you learn that something you like to do anyway is even better for you than you realized.


🆔 @Internalmed
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Internal Medicine (5.4k)

02 Feb 2024 19:01

💢 آیا باید از سرخک بترسیم؟


این روزها خبرهای زیادی از اطراف و اکناف دنیا و از جمله همسایگان خودمان درباره outbreak های سرخک می‌شنویم.

خواندن این مطلب مفید را به همکاران محترم توصیه می‌کنم.


🆔 @Internalmed
.

Internal Medicine (5.4k)

30 Jan 2024 20:00

💢 Updates in nonalcoholic fatty liver disease


🆔 @Internalmed
.

Internal Medicine (5.4k)

29 Jan 2024 22:08

💢 Diagnosis and management of polycystic ovarian syndrome


🆔 @Internalmed
.

Internal Medicine (5.4k)

28 Jan 2024 21:04

💢 Covid-19 Vaccines have saved at least 1.4 million lives in Europe, WHO reports


🆔 @Internalmed
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Internal Medicine (5.4k)

26 Jan 2024 10:27

💢 Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity.

🗞 Scientific Reports. 2023 Nov 28;13(1):20998. 10.1038/s41598-023-48267-2


Researchers from Virginia Tech found that drugs used for treating Type 2 diabetes and obesity, such as Semaglutide and tirzepatide, reported a reduction in cravings for alcohol in social media posts on Reddit.


🍻 Social Media Reports: Users on Reddit reported reduced cravings for alcohol when taking drugs intended for Type 2 diabetes and obesity.

📚 Virginia Tech researchers analyzed over 68,000 Reddit posts and conducted a remote study on individuals with obesity using Semaglutide and tirzepatide.

🍽 Semaglutide is a GLP-1 agonist, a drug class reducing blood sugar and energy intake, mimicking post-eating hormonal actions.

🧹 Data Cleaning: After cleaning the data, 33,609 posts from 14,595 unique users were narrowed down from the initial Reddit analysis.

📊 Among 1,580 alcohol-related posts, 71.7% addressed reduced cravings and negative effects due to drinking.

🧪 153 participants with obesity, using Semaglutide or Tirzepatide, reported significantly fewer drinks and lower odds of binge drinking compared to the control group.

🚫 FDA-approved medications for alcohol use disorder have modest success, and researchers suggest exploring GLP-1 agonists' therapeutic potential.

🌎 Demographic Gap: The study participants were mostly white and female, emphasizing the need for more diverse studies on sex and race differences.

🤔 Underlying Mechanisms: Despite growing evidence, researchers aim to understand more about the underlying mechanisms and contribute to further studies.

🌐 Global Impact: Alcohol use disorder affects 5.9% of individuals in the United States, and the drugs show promise in addressing this undertreated condition.

Why this matters
📈 GLP-1 agonists show unexpected side effects in reducing addictive behaviors, hinting at a potential treatment for alcohol use disorder.

🏛 Existing FDA-approved medications for alcohol use disorder have limitations, leading to a need for more effective alternatives.

🔍 Authors recommend further randomized controlled trials to explore GLP-1 agonists' therapeutic potential and address demographic gaps.


🆔 @Internalmed
.